Research Articles
Chemoinformatic Analysis of Natural Product Libraries: Accelerating Modern Drug Discovery
This article provides a comprehensive overview of the application of chemoinformatics in the analysis of natural product (NP) libraries for drug discovery.
Natural Product Fragments and Functional Groups: A Comparative Analysis for Modern Drug Discovery
This article provides a comprehensive comparative analysis of natural product (NP) fragments and their characteristic functional groups, exploring their unique role in addressing contemporary drug discovery challenges.
Target Identification and Validation for Natural Products: Advanced Strategies for Unlocking Nature's Pharmacy
Target identification and validation are critical, foundational steps in modern natural product-based drug discovery, transforming traditional remedies into targeted therapeutics with understood mechanisms of action.
Terrestrial vs. Marine Natural Products: A Comparative Analysis of Chemical Diversity and Therapeutic Potential in Drug Discovery
This review provides a comprehensive comparative analysis of natural products derived from terrestrial and marine environments, focusing on their distinct chemical properties, biological activities, and applications in modern drug discovery.
Evaluating Chemical Similarity Methods for Natural Products: From Foundations to Advanced Applications in Drug Discovery
Chemical similarity calculation is a cornerstone of cheminformatics, crucial for ligand-based virtual screening and drug discovery.
Validating the Biological Relevance of Natural Product-Inspired Compounds: Strategies for Drug Discovery
This article provides a comprehensive guide for researchers and drug development professionals on establishing the biological relevance of natural product (NP)-inspired compounds.
Ring Systems in Drug Discovery: A Comparative Analysis of Natural Product and Synthetic Compound Architectures
This article provides a comprehensive comparative analysis of ring systems found in natural products (NPs) and synthetic compounds, tailored for researchers and drug development professionals.
Molecular Mechanisms of Natural Products in Inflammation and Cancer: From Pathways to Precision Therapeutics
Chronic inflammation is a critical hallmark and driver of cancer, underlying up to 60% of all deaths worldwide.
Cheminformatic Analysis in Drug Discovery: A Comparative Study of Natural Products and Synthetic Compounds
This article provides a comprehensive cheminformatic comparison of natural products (NPs) and synthetic compounds (SCs), crucial sources for small-molecule drug discovery.
Securing the Source: Strategies for Solving Rare Natural Product Supply Chain Challenges in Biomedical Research
This article addresses the critical supply chain vulnerabilities that threaten research and development of rare natural products, from earth minerals to bioactive compounds.